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The workflow chart of the easyEWAS. Abbreviations: DNAm, DNA methylation; DMP, differentially methylated position; DMR, differentially methylated region; GLM, general linear model; LMM, linear mixed-effects model; CoxPH, Cox proportional hazards model; QQ: quantile–quantile; Boot.CI, bootstrap-derived CI; KEGG, Kyoto Encyclopedia of Genes and Genomes.

Journal: Bioinformatics Advances

Article Title: easyEWAS: a flexible and user-friendly R package for epigenome-wide association study

doi: 10.1093/bioadv/vbaf026

Figure Lengend Snippet: The workflow chart of the easyEWAS. Abbreviations: DNAm, DNA methylation; DMP, differentially methylated position; DMR, differentially methylated region; GLM, general linear model; LMM, linear mixed-effects model; CoxPH, Cox proportional hazards model; QQ: quantile–quantile; Boot.CI, bootstrap-derived CI; KEGG, Kyoto Encyclopedia of Genes and Genomes.

Article Snippet: In conclusion, easyEWAS is an R package that can be easily integrated into various DNA methylation microarrays detected by Illumina HumanMethylation Bead Chip, significantly enhancing the accessibility of EWAS.

Techniques: DNA Methylation Assay, Methylation, Derivative Assay

The function names and their corresponding functionalities within the easyEWAS package.

Journal: Bioinformatics Advances

Article Title: easyEWAS: a flexible and user-friendly R package for epigenome-wide association study

doi: 10.1093/bioadv/vbaf026

Figure Lengend Snippet: The function names and their corresponding functionalities within the easyEWAS package.

Article Snippet: In conclusion, easyEWAS is an R package that can be easily integrated into various DNA methylation microarrays detected by Illumina HumanMethylation Bead Chip, significantly enhancing the accessibility of EWAS.

Techniques: DNA Methylation Assay, Methylation, Biomarker Discovery

Establishment of mouse RILF model and analysis of transcriptome microarray data analysis. (A) HE and masson staining of lung tissue collected at 20 weeks after IR (control, 17 Gy). Lungs treated to 17 Gy dose irradiation develop foci of fibrosis. Collagen: blue; cytoplasm/epithelia: pink. Scale bar = 20 μm. (B) The PCA plot of the distribution status of the two groups (C) Volcano plots displaying significantly differentially expressed genes. |log2FC| ≥ 0.5 and P < 0.05. (D) Heatmap displaying the expressions of the DEGs. Blue corresponds to lower gene expression and red to higher gene expression. (E) Bar plot of enriched KEGG pathways/GO terms showing DEGs.

Journal: Dose-Response

Article Title: Ferroptosis-Associated Extracellular Matrix Remodeling in Radiation-Induced Lung Fibrosis Progression

doi: 10.1177/15593258241289829

Figure Lengend Snippet: Establishment of mouse RILF model and analysis of transcriptome microarray data analysis. (A) HE and masson staining of lung tissue collected at 20 weeks after IR (control, 17 Gy). Lungs treated to 17 Gy dose irradiation develop foci of fibrosis. Collagen: blue; cytoplasm/epithelia: pink. Scale bar = 20 μm. (B) The PCA plot of the distribution status of the two groups (C) Volcano plots displaying significantly differentially expressed genes. |log2FC| ≥ 0.5 and P < 0.05. (D) Heatmap displaying the expressions of the DEGs. Blue corresponds to lower gene expression and red to higher gene expression. (E) Bar plot of enriched KEGG pathways/GO terms showing DEGs.

Article Snippet: Gene expression was detected using a transcriptome microarray (Mouse Sentrix-6 V2 Whole Genome Bead Chip, BD-201-0202; Illumina, Inc., San Diego, CA, USA).

Techniques: Microarray, Staining, Control, Irradiation, Gene Expression